Objectives To evaluate the relative translucency parameter (RTP) values of computer-aided design (CAD)-computer-aided manufacturing (CAM) materials after UV aging. Materials and methods 70 specimens (n = 10) of Bruxzir Anterior (BA); E.max Cad (EC); Lava Ultimate (LU); Cerasmart (CE); Vita Enamic (VE); Vita Suprinity (VS); Vita Mark II (VM) were prepared (1 mm +/- 0.01 mm). Color measurements were performed using a spectrofotometer (VITA Easyshade). RTP values of the specimens before (RTP1) and after UV aging (RTP2) were evaluated. Statistical analyses were done with repeated measurements of two-way-ANOVA with Bonferroni test (P < 0.05). Results Evaluating RTP1 and RTP2 values; significant differences were found (P < 0.05). There were no significant difference between the RTP1 values of CE and VS (P = 0.779); EC and VM (P = 0.952); VM and LU (P = 0.995); EP and LU (P = 0.653). Evaluating RTP2 values; VE and BA were found significantly different from the others (P < 0.05). For all evaluated groups TP values decreased after UV aging (P < 0.05). The most RTP reduction was observed for LU; while VM and EC were less affected. Conclusion Glass ceramic VE showed the highest RTP and zirconia-based BA was the most opaque restorative CAD-CAM material. UV aging caused the CAD-CAM materials get more opaque. Clinical significance In cases where translucency is needed chosing VE would give better esthetic results; while zirconia-based BA should be used if more opaque restoration is needed. Clinicians should be aware of that restorations get more opaque after usage.