Long-term disability trajectories in primary progressive MS patients: A latent class growth analysis

Signori, Alessio; Izquierdo, Guillermo; Lugaresi, Alessandra; Hupperts, Raymond; Grand'Maison, Francois; Sola, Patrizia; Horakova, Dana; Havrdova, Eva; Prat, Alexandre; Girard, Marc; Duquette, Pierre; BOZ, CAVİT; Grammond, Pierre; TERZİ, MURAT; Singhal, Bhim; Alroughani, Raed; Petersen, Thor; Ramo, Cristina; Oreja-Guevara, Celia; Spitaleri, Daniele; Shaygannejad, Vahid; Butzkueven, Helmut; Kalincik, Tomas; Jokubaitis, Vilija; Slee, Mark; Fernandez Bolanos, Ricardo; Luis Sanchez-Menoyo, Jose; Pucci, Eugenio; Granella, Franco; Lechner-Scott, Jeannette; Iuliano, Gerardo; Hughes, Stella; Bergamaschi, Roberto; Taylor, Bruce; Verheul, Freek; Rio, Maria; Amato, Maria; Sajedi, Seyed; Majdinasab, Nastaran; Van Pesch, Vincent; Sormani, Maria; Trojano, Maria

doi:10.1177/1352458517703800

Long-term disability trajectories in primary progressive MS patients: A latent class growth analysis

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Signori A., Izquierdo G., Lugaresi A., Hupperts R., Grand'Maison F., Sola P., ...More

MULTIPLE SCLEROSIS JOURNAL, vol.24, no.5, pp.642-652, 2018 (SCI-Expanded)

Publication Type: Article / Article
Volume: 24 Issue: 5
Publication Date: 2018
Doi Number: 10.1177/1352458517703800
Journal Name: MULTIPLE SCLEROSIS JOURNAL
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.642-652
Keywords: Primary progressive multiple sclerosis, disability, long-term, trajectories, clinical trials, heterogeneity, MULTIPLE-SCLEROSIS, NATURAL-HISTORY, DOUBLE-BLIND, MULTICENTER, PHASE
Karadeniz Technical University Affiliated: Yes

Abstract

Background: Several natural history studies on primary progressive multiple sclerosis (PPMS) patients detected a consistent heterogeneity in the rate of disability accumulation.