The Projective Effect of Pomegranate Juice on Fibrosis, Carboxylesterase Activity and Fatty Acid Profile in Rat Liver Tissues Exposed to Carbon Tetrachloride

Ozkaya A., ŞAHİN Z., Bulbul S. C., Uckun M., Yologlu E., Turk A., ...Daha Fazla

Journal of the Chemical Society of Pakistan, cilt.47, sa.2, ss.155-164, 2025 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Sayı: 2
  • Basım Tarihi: 2025
  • Doi Numarası: 10.52568/001640/jcsp/47.02.2025
  • Dergi Adı: Journal of the Chemical Society of Pakistan
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Analytical Abstracts, Chemical Abstracts Core
  • Sayfa Sayıları: ss.155-164
  • Anahtar Kelimeler: Carbon tetrachloride, Carboxylesterase, Fatty acids, Liver, Pomegranate juice, Rat
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

In this study, it was aimed to investigate the effects of pomegranate juice (PJ) on liver carboxylesterases (Ces), oxidative stress parameters, liver histology, and fatty acids in rats exposed to carbon tetrachloride (CCl4). Adult male Wistar albino rats were randomly divided into four groups as control, CCl4, PJ, and CCl4+PJ (n=7 in each group). We determined that the decrease in Ces activity due to CCl4-induced liver damage was alleviated by PJ. Moreover, PJ reduced CCl4-induced oxidative stress, liver degeneration, and apoptosis. While the CCl4 group increased the 15:0, 16:0 fatty acid levels, it decreased the 20:4 and PUFA fatty acid levels compared to the control group. In the CCl4+PJ group, 16:0 and ΣSFA fatty acid percentages decreased with the effect of PJ compared to the CCl4 group, while 18:2n-6, ΣPUFA and ΣUSFA fatty acid ratios increased. We concluded that PJ has an ameliorative effect on liver damage caused by CCl4 exposure.