Investigation of the effect of trazodone on spontaneous and acetylcholine-induced bladder detrusor smooth muscle contractions


Burunsuz Ö., Özdengül F., Gıca Ş., Şen A., Şahin Z.

Dusunen Adam:The Journal of Psychiatry and Neurological Sciences, vol.35, pp.43-47, 2022 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 35
  • Publication Date: 2022
  • Doi Number: 10.14744/dajpns.2022.00170
  • Journal Name: Dusunen Adam:The Journal of Psychiatry and Neurological Sciences
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, EMBASE, Psycinfo, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.43-47
  • Keywords: Antidepressant, bladder, detrusor, smooth muscle contraction, trazodone, UNITED-STATES EXPERIENCE, PIG URINARY-BLADDER, RECEPTOR SUBTYPES, ANTIDEPRESSANTS, STIMULATION, ATROPINE
  • Karadeniz Technical University Affiliated: Yes

Abstract

Objective: The management of psychiatric patients is often complicated by medical comorbidities, complex pharmacological regimens, and side effects secondary to these regimens. In the current study, it was aimed to investigate the effects and mechanism of action of trazodone on rat bladder smooth muscle contractility in vitro.