Antimicrobial and lipase inhibition of essential oil and solvent extracts of Cota tinctoria var. tinctoria and characterization of the essential oil

ERİK İ., BOZDAL G., ŞENER S. Ö., KORKMAZ B., ALPAY KARAOĞLU Ş., TERZİOĞLU S., ...Daha Fazla

TURKISH JOURNAL OF CHEMISTRY, cilt.46, sa.4, ss.1234-1244, 2022 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46 Sayı: 4
  • Basım Tarihi: 2022
  • Doi Numarası: 10.55730/1300-0527.3430
  • Dergi Adı: TURKISH JOURNAL OF CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.1234-1244
  • Anahtar Kelimeler: Antimicrobial, Cola tinctoria var, tinctoria, GC-FID/MS, lipase inhibition, volatile compounds, CHEMICAL-COMPOSITION, VOLATILE CONSTITUENTS, MEDICINAL-PLANTS, ANTHEMIS-WIEDEMANNIANA, ANTIOXIDANT ACTIVITY, GC-MS, ASTERACEAE, FLOWERS, CLASSIFICATION, COMPONENTS
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

The essential oil (EO) of Cota tinctoria var. tinctoria was analyzed using GC-FID/MS. A total of 51 compounds were determined from this taxon, accounting for 99.79% in hydrodistillation. Monoterpenes were the primary chemical class for the volatile organic compounds in the EO (36.1%, 13 compounds). Borneol (18.1%), camphor (14.9%), and beta-pinene (11.3%) were the major components in the EO of C tinctoria var. tinctoria. The antimicrobial activities of EO and n-hexane, acetonitrile, methanol, and water solvent extracts of the taxon were screened in vitro against ten microorganisms. The EO yielded the best activity (15 mm, 372.5 MIC, 59600 mu g/pL) against Mycobacterium smegmatis. The acetonitrile extract was the most active against the Staphylococcus aureus and Bacillus cereus with 274 mu g/mL MIC value. IC50 values for the lipase enzyme inhibitory activity of EO and solvent extracts (n-hexane, acetonitrile, methanol, and water) were found to be 59.80 +/- 4.3285 mu g/mL 68.28 +/- 3.1215 mu g/mL, 52.60 +/- 3.7526 mu g/mL, 48.73 +/- 2.8265 mu g/mL, and 99.50 +/- 5.5678 mu g/mL, respectively.