Antimicrobial and lipase inhibition of essential oil and solvent extracts of Cota tinctoria var. tinctoria and characterization of the essential oil
TURKISH JOURNAL OF CHEMISTRY, cilt.46, sa.4, ss.1234-1244, 2022 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 46 Sayı: 4
- Basım Tarihi: 2022
- Doi Numarası: 10.55730/1300-0527.3430
- Dergi Adı: TURKISH JOURNAL OF CHEMISTRY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.1234-1244
- Anahtar Kelimeler: Antimicrobial, Cola tinctoria var, tinctoria, GC-FID/MS, lipase inhibition, volatile compounds, CHEMICAL-COMPOSITION, VOLATILE CONSTITUENTS, MEDICINAL-PLANTS, ANTHEMIS-WIEDEMANNIANA, ANTIOXIDANT ACTIVITY, GC-MS, ASTERACEAE, FLOWERS, CLASSIFICATION, COMPONENTS
- Karadeniz Teknik Üniversitesi Adresli: Evet
Özet
The essential oil (EO) of Cota tinctoria var. tinctoria was analyzed using GC-FID/MS. A total of 51 compounds were determined from this taxon, accounting for 99.79% in hydrodistillation. Monoterpenes were the primary chemical class for the volatile organic compounds in the EO (36.1%, 13 compounds). Borneol (18.1%), camphor (14.9%), and beta-pinene (11.3%) were the major components in the EO of C tinctoria var. tinctoria. The antimicrobial activities of EO and n-hexane, acetonitrile, methanol, and water solvent extracts of the taxon were screened in vitro against ten microorganisms. The EO yielded the best activity (15 mm, 372.5 MIC, 59600 mu g/pL) against Mycobacterium smegmatis. The acetonitrile extract was the most active against the Staphylococcus aureus and Bacillus cereus with 274 mu g/mL MIC value. IC50 values for the lipase enzyme inhibitory activity of EO and solvent extracts (n-hexane, acetonitrile, methanol, and water) were found to be 59.80 +/- 4.3285 mu g/mL 68.28 +/- 3.1215 mu g/mL, 52.60 +/- 3.7526 mu g/mL, 48.73 +/- 2.8265 mu g/mL, and 99.50 +/- 5.5678 mu g/mL, respectively.