EFFECT OF SUCRALFATE ON GASTRIC-EMPTYING AND MUCUS UNDER STRESS IN RATS

ALHAN E., KUCUKTULU U., CALIK A., CINEL A.

ISRAEL JOURNAL OF MEDICAL SCIENCES, cilt.31, sa.6, ss.356-359, 1995 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Sayı: 6
  • Basım Tarihi: 1995
  • Dergi Adı: ISRAEL JOURNAL OF MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.356-359
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

The effect of sucralfate on gastric emptying, gastric mucus production, and ulcer formation in cold-restraint rats was studied. The rats were treated with sucralfate in doses of 100 mg/kg, 250 mg/kg and 500 mg/kg. Sucralfate prevented ulcer formation dose dependently. This effect was maximum at doses of 500 mg/kg (P <0.001). Administration of sucralfate lowered the increased gastric emptying rate and increased gastric mucus production. This effect was not dose dependent. It was found that the ulcer-preventive effect of sucralfate was due to a lowered gastric emptying rate and increased mucus production in addition to other mechanisms.
Abstract

The effect of sucralfate on gastric emptying, gastric mucus production, and ulcer formation in cold-restraint rats was studied. The rats were treated with sucralfate in doses of 100 mg/kg, 250 mg/kg and 500 mg/kg. Sucralfate prevented ulcer formation dose dependently. This effect was maximum at doses of 500 mg/kg (P <0.001). Administration of sucralfate lowered the increased gastric emptying rate and increased gastric mucus production. This effect was not dose dependent. It was found that the ulcer-preventive effect of sucralfate was due to a lowered gastric emptying rate and increased mucus production in addition to other mechanisms.