The Biological Activity; Cytotoxicity and Antioxidant Activity of Jurinea brevicaulis


ABUDAYYAK M., KANBOLAT Ş., Batur Ş., ERGENE R. S., ALİYAZICIOĞLU R.

KSU TARIM VE DOGA DERGISI-KSU JOURNAL OF AGRICULTURE AND NATURE, vol.24, pp.278-284, 2021 (ESCI) identifier identifier

Abstract

Jurinea brevicaulis is a perennial herbaceous plant belonging to the Asteraceae family. J. brevicaulis is an endemic genus and grows Erzincan and Gumushane provinces in Turkey. Jurinea species are known to have anticancer, antibacterial, antifungal and antioxidant effects. In this article, it is aimed to evaluate the antioxidant capacity and cytotoxic effects of J. brevicaulis. Results indicate that, TPC values were between 41.7 - 537.5 GAE mu g g(-1), FRAP values were between 109.52 - 1076.2 mu M Trolox equivalent g(-1), CUPRAC values were between 231.4 - 3083.3 mu M Trolox equivalent g(-1), IC50 values in DPPH determination were between 0.0102 - 3.4174 mg mL(-1). The extracts caused cell death in a concentration-dependent manner in, IC50 values were calculated to be between 3.67-10.2 mu g mL(-1). In conclusion, the cytotoxic effects in cancerous cells and the high antioxidant capacity indicates that J. brevicaulis could be an important herb in developing new drugs.