Investigation of the Skin-Related Enzyme Inhibitory, Antioxidant Activity and Phenolic Profile of Satureja spicigera (K.Koch) Boiss.

Subaş T., Kanbolat Ş., Badem M., Ulaş Çolak N., Başköse İ., Sarıçam S., ...Daha Fazla

18th OPTIMA Meeting , Nevşehir, Türkiye, 22 - 26 Eylül 2026, ss.59, (Özet Bildiri)

  • Yayın Türü: Bildiri / Özet Bildiri
  • Basıldığı Şehir: Nevşehir
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.59
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Global interest in and demand for cosmetic products is increasing steadily. Owing to their secondary metabolites, plants constitute important natural sources for the development of dermocosmetic products [1]. Satureja species (Lamiaceae) are used both as food and for medicinal purposes in the treatment of ailments such as nausea, diarrhea, cramps, and indigestion [2]. This study aimed to evaluate the potential dermocosmetic applicability of the aerial parts (leaves and stems) of S. spicigera and to determine its phenolic profile. The collagenase and tyrosinase inhibitory activities of the methanol extract, along with its chloroform, ethyl acetate, and remaining aqueous subextracts, prepared from the species, were evaluated spectrophotometrically, and their antioxidant activity was assessed using the ABTS•+ (2,2-azino-bis-3-ethylbenzothiazoline-6-sulphonic acid) radical scavenging assay. The phenolic profile of the extracts was investigated using high-performance liquid chromatography (HPLC). Although the extracts exhibited weaker enzyme inhibitory activity compared with the positive controls (catechin, kojic acid), the ethyl acetate subextract was found to be more effective than the other extracts (IC50 for collagenase: 40.786 ± 0.874 μg/mL; for tyrosinase: 51.328 ± 2.705 μg/mL). The ethyl acetate subextract also showed the highest ABTS•+ radical scavenging capacity (559.294 ± 6.487 μM). Among the phenolic compounds of the ethyl acetate subextract, rosmarinic acid (441.576 ppm), vanillic acid (7.4544 ppm), p-coumaric acid (5.6264 ppm), and p-hydroxybenzoic acid (4.6048 ppm) were identified as the major constituents. It was determined that S. spicigera, and particularly its ethyl acetate subextract, shows potential as a natural raw material for dermocosmetic products; however, further studies are required.