Serum carbonic anhydrase autoantibodies in metabolic syndrome

ALVER A., MENTEŞE A., Erem C., DEĞER O., Koçak M., Keha E. E.

Diabetes and Metabolic Syndrome: Clinical Research and Reviews, vol.3, no.4, pp.211-213, 2009 (SCI-Expanded) identifier



Carbonic anhydrase (CA) autoantibodies have been observed in various autoimmune and idiopathic diseases right now. The aim of this study was to investigate the presence of anti-carbonic anhydrase I and II antibodies in subjects with metabolic syndrome (MetS).


43 subjects with MetS and 30 non-MetS subjects (controls) were included in the study. Carbonic anhydrase autoantibodies were screened by ELISA.


Anti-CA I antibody was detected in 7 of 43 subjects with MetS. The antibody-positive prevalence of MetS group (16%) was found to be significantly higher compared with that of control group (p < 0.05). There were no significant changes in positive rate of anti-CA II antibody. Positive results were obtained in 2 of 43 subjects with MetS.


Anti-CA I antibodies were present in sera obtained from MetS subject and these antibodies may be involved in pathogenesis of MetS.