Hormonal and histological changes in the ovaries with high-doses of methylprednisolone administration for acute spinal cord injury: An experimental study

OSMANAĞAOĞLU M. A. , USUL H., YULUĞ E., KESIM M., KARAHAN S. C.

Journal of Obstetrics and Gynaecology, vol.33, no.6, pp.585-590, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 6
  • Publication Date: 2013
  • Doi Number: 10.3109/01443615.2013.789833
  • Journal Name: Journal of Obstetrics and Gynaecology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.585-590
  • Keywords: Methylprednisolone, ovarian damage, ovarian reserve, rats, spinal cord injury, LIPID-PEROXIDATION, TIRILAZAD MESYLATE, GLUCOCORTICOIDS, EXPRESSION, MELATONIN
  • Karadeniz Technical University Affiliated: Yes

Abstract

This study was conducted to investigate the hormonal and histological changes in the ovaries with high doses of methylprednisolone administration for acute spinal cord injury (SCI). Group I (trauma group, eight rats) were subjected to laminectomy and SCI but received no treatment. Group II (steroid group, eight rats) were subjected to SCI and received methylprednisolone (30 mg/kg, intraperitoneally). Group III (control group, six rats) underwent a sham operation without trauma and treatment. Malondialdehyde (MDA) levels were significantly decreased in Group II (p < 0.05). The scores of histopathological damage of the ovaries in the three groups were found to be statistically comparable (p > 0.05). Serum anti-Müllerian hormone (AMH) levels in the steroid group was significantly lower compared with the control group (p < 0.05). High-dose methylprednisolone administration may effect ovarian reserve with reversible ovarian damage and can resolve lipid peroxidation in rats with spinal cord injury. © 2013 Informa UK, Ltd.