Control of bovine viral diarrhoea infections through vaccination

Kalaycioglu A. T.

KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI, vol.13, no.1, pp.103-108, 2007 (SCI-Expanded) identifier

  • Publication Type: Article / Review
  • Volume: 13 Issue: 1
  • Publication Date: 2007
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.103-108
  • Keywords: bovine viral diarrhoea, antigenic diversity, vaccine efficacy and safety, novel developments, FETAL PROTECTION, IMMUNE-RESPONSES, GLYCOPROTEIN E2, MUCOSAL DISEASE, VIRUS-VACCINE, BVDV TYPE-2, CATTLE, PESTIVIRUSES, CALVES, CHALLENGE
  • Karadeniz Technical University Affiliated: No


The main goal of BVDV vaccination is to induce adequate immunity in dams for protecting the infection of foetuses against both genotypes of BVDV-1 and BVDV-2 viruses during pregnancy and thus preventing the establishment of persistent infections as well as preventing severe postnatal infections caused by BVDV-2. The most important problem for BVDV vaccine development is the existence of diversity of BVDV isolates in worldwide. So far, a few BVDV vaccines and vaccination strategies have been given good results for preventing transplacental infections. Live-attenuated BVDV vaccines are better for protection but they have safety concerns. Inactivated vaccines are questionable for inducing adequate broad immune response. There is still a necessity for the development of a better and a novel vaccine for the control of BVDV infections.