Electrochemical Analysis of Antipsychotic Drug Quetiapine Fumarate Using Multi-walled Carbon Nanotube Modified Glassy Carbon Electrode

Kaynar B., ÖZTÜRK G., KUL D.

ELECTROANALYSIS, vol.35, no.3, 2023 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 3
  • Publication Date: 2023
  • Doi Number: 10.1002/elan.202200057
  • Journal Name: ELECTROANALYSIS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Applied Science & Technology Source, BIOSIS, Chemical Abstracts Core, Chimica, Communication Abstracts, Metadex, Civil Engineering Abstracts
  • Keywords: Carbon nanotube, Glassy carbon electrode, Quetiapine, Validation, SENSITIVE VOLTAMMETRIC DETERMINATION, TANDEM MASS-SPECTROMETRY, ASCORBIC-ACID, HUMAN PLASMA, COMPOSITE, LIQUID, SENSOR, XR, PHARMACEUTICALS, METABOLITES
  • Karadeniz Technical University Affiliated: Yes

Abstract

Electrochemical properties of quetiapine fumarate were examined on the anodic direction with multi-walled carbon nanotube modified glassy carbon electrode using voltammetric methods. The ratio of multi-walled carbon nanotube has been optimized using its various concentrations. The oxidation process was found to be irreversible, and adsorption controlled. The linear ranges were determined as 4x10(-9)-2x10(-6) M for differential pulse stripping voltammetry and 2x10(-9)-2x10(-6) M for square-wave stripping voltammetry with detection limits of 8.07x10(-10) and 2.71x10(-10) M, respectively. The methods were validated and successfully applied for the analysis of quetiapine fumarate tablets. The groups responsible for the oxidation reaction of quetiapine fumarate were investigated with model substances.