Green Research on Automation and Sample Preparation (GRASP) LAB

Welcome to the GRASP Research Group

Our group redefines "Sample Preparation" and "Separation"-the most critical stages of Analytical Chemistry-through the principles of Green Chemistry.

Our Focus Areas at GRASP Group:

  • Green Sample Preparation: The utilization of next-generation green solvents, such as Deep Eutectic Solvents (DES).

  • Automation & Flow Systems: The development of closed-system architectures free from human error, employing Lab-In-Syringe and flow injection techniques.

  • Liquid Chromatography (LC): The development of liquid chromatographic methods for the precise determination of trace components within complex matrices.

Ultimately, we provide "smart, automated, and green" analytical strategies to address the limitations and environmental burdens of traditional methods.

Recent Publications

Formulation Optimization for ALA-Loaded Lipid-Polymer Hybrid Nanoparticles via the Design of Experiments

ÇOBAN Ö., DEMİRTAŞ H., YILDIRIM S., REZA M. M.
International Multidisciplinary Symposium on Drug Research and Development (DRD 2023), İzmir, Turkey, 4 - 06 May 2023, pp.210, (Summary Text)

Comprehensive Analysis of Hedysarum nitidum: Identification Phytochemical Contents, Antioxidant Potential, Antimicrobial Properties, Cytotoxic Effects, and Enzyme Inhibition Activities

Baltürk N., BADEM M., KANBOLAT Ş., YILDIRIM S., Şen T. M., BOZDAL G., et al.
Chemistry and Biodiversity, vol.22, no.10, 2025 (SCI-Expanded, Scopus)

Insights into the binding interactions of Macitentan to bovine serum Albumin: A Spectroscopic, electrochemical and computational study

SADAK S., Dindar Ç. K., Kabir M., Rehman F., Mohamad S. B., YILDIRIM S., et al.
Journal of Molecular Liquids, vol.429, 2025 (SCI-Expanded, Scopus)

Formulation Optimization and in Vitro-in Vivo Evaluation of Alpha Lipoic Acid-Loaded Lipid-Polymer Hybrid Nanoparticles Via Design of Experiments

ÇOBAN Ö., DEMİRTAŞ H., KAYA YAŞAR Y., ENGİN S., YILDIRIM S., Morsali M. R.
JOURNAL OF PHARMACEUTICAL INNOVATION, vol.20, no.2, 2025 (SCI-Expanded, Scopus)

Lab-in-syringe automated dispersive solid-phase microextraction of alkylphenols coupled online to liquid chromatography using iron (III) thenoyltrifluoroacetonate as dissolvable sorbent

Moe Htet T. T., Gemuh C. V., YILDIRIM S., Sklenářová H., Solich P., Horstkotte B.
Analytica Chimica Acta, vol.1345, 2025 (SCI-Expanded, Scopus)

Farklı İzoksazolil Grubu İçeren Silisyum Ftalosiyaninlerin Sentezi, DNA Bağlama ve Nöroblastoma (SH-SY5Y) Hücre Hattına Karşı Sitotoksisite ve Fototoksisite Çalışmaları

Yalazan H., Barut B., Yıldırım S., Yalçın C. Ö., Kantekin H.
VIII. Ulusal Anorganik Kimya Kongresi, Tekirdağ, Turkey, 2 - 05 September 2021, pp.93, (Summary Text)

DEVELOPMENT OF A GREEN HPLC METHOD USING ETHANOL IN THE MOBILE PHASE COMPOSITION FOR THE DETERMINATION OF SODIUM BENZOATE AND POTASSIUM SORBATE IN BEVERAGES

YILDIRIM S.
Ankara Üniversitesi Eczacılık Fakültesi Dergisi, vol.48, no.3, pp.1078-1088, 2024 (Scopus, TRDizin)

Surfactant-Based Electrochemical Devices for the Determination of Pesticides

Çelik M., ERKMEN C., YILDIRIM S., USLU B.
in: Advances in Surfactant Biosensor and Sensor Technologies, , Editor, Springer, pp.43-68, 2024

Future trends of nanomaterials in environmental analysis

SİLAH H., ERKMEN C., YILDIRIM S., USLU B.
in: Nanomaterials in Environmental Analysis, , Editor, Elsevier Inc., pp.455-471, 2024

A Deep Eutectic Solvent-Based Ferrofluid for Vortex-Assisted Liquid-Liquid Microextraction of Nonsteroidal Anti-Inflammatory Drugs from Environmental Waters

Yıldırım S.
PBA2023-33rd International Symposium on Pharmaceutical and Biomedical Analysis, Ankara, Turkey, 2 - 06 July 2023, pp.110, (Summary Text)